--- title: "Survodutide — The GLP-1/Glucagon Dual Agonist for Weight Loss & Liver Health | Pause & Reset" description: "Survodutide is a dual GLP-1/glucagon agonist in Phase 3 trials showing 19% weight loss AND dramatic liver fat reduction. Here's what it does, who it's for, and when it might be available." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": [ "MedicalBusiness", "LocalBusiness" ], "name": "Pause & Reset", "description": "Atlanta's dedicated perimenopause and menopause practice offering bioidentical hormone therapy, comprehensive hormone testing, GLP-1 weight loss management, peptide therapy, IV nutrient therapy, hyperbaric oxygen therapy, and functional medicine in Dunwoody GA.", "url": "https://pausereset.com", "telephone": "+14044458344", "email": "hello@pausereset.com", "image": "https://pausereset.com/assets/logo-Cj2twgJt.webp", "priceRange": "$$$$", "paymentAccepted": "Cash, Credit Card", "currenciesAccepted": "USD", "openingHours": [ "Mo-Fr 10:00-16:30", "Sa 09:00-15:30" ], "address": { "@type": "PostalAddress", "streetAddress": "8735 Dunwoody Place, Suite 110", "addressLocality": "Atlanta", "addressRegion": "GA", "postalCode": "30350", "addressCountry": "US" }, "geo": { "@type": 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and menopause symptoms." }, { "@type": "MedicalTherapy", "name": "GLP-1 Weight Loss Management", "description": "Semaglutide and tirzepatide prescribed alongside hormone optimization for menopause-related weight management." }, { "@type": "MedicalTherapy", "name": "Peptide Therapy", "description": "Evidence-based peptide protocols for tissue repair, sleep, body composition, immune support, and recovery during midlife." }, { "@type": "MedicalTherapy", "name": "IV Nutrient Therapy", "description": "Lab-guided intravenous nutrient infusions customized to documented deficiencies for perimenopause and menopause support." }, { "@type": "MedicalTherapy", "name": "Hyperbaric Oxygen Therapy", "description": "Pressurized oxygen therapy for tissue repair, inflammation reduction, and cellular recovery during the menopause transition." }, { "@type": "MedicalTherapy", "name": "EBOO Ozone Therapy", "description": "Blood oxygenation and filtration therapy for inflammation, immune support, and detoxification during perimenopause and menopause." }, { "@type": "MedicalTest", "name": "Comprehensive Hormone Testing", "description": "15+ marker hormone panel including estradiol, progesterone, testosterone, full thyroid, insulin, and nutrient levels." }, { "@type": "MedicalTest", "name": "DUTCH Hormone Testing", "description": "Dried urine testing for hormone metabolism pathways showing how the body processes and clears estrogen." }, { "@type": "MedicalTherapy", "name": "Pelvic Floor Rehabilitation", "description": "Treatment for urinary leaking, urgency, and painful intercourse caused by menopause-related tissue and muscle changes." }, { "@type": "MedicalTherapy", "name": "Medical Weight Loss", "description": "Comprehensive metabolic evaluation and treatment for menopause-related weight gain including hormones, GLP-1, and nutrition." }, { "@type": "MedicalTherapy", "name": "Nutrition and Metabolic Counseling", "description": "Personalized nutrition, supplementation, and metabolic strategy for women in perimenopause and menopause." } ] }, "sameAs": [ "https://www.instagram.com/pausenresetco", "https://atlantatrichology.com", "https://ninaross.co" ], "founder": { "@type": "Person", "name": "Dr. Nina Ross", "jobTitle": "Menopause Specialist", "url": "https://ninaross.co", "sameAs": [ "https://ninaross.co", "https://atlantatrichology.com" ] } }, { "@context": "https://schema.org", "@type": "MedicalTherapy", "name": "survodutide", "description": "Survodutide is a dual GLP-1/glucagon agonist in Phase 3 trials showing 19% weight loss AND dramatic liver fat reduction. Here's what it does, who it's for, and when it might be available.", "indication": [ { "@type": "MedicalIndication", "name": "survodutide weight loss" }, { "@type": "MedicalIndication", "name": "survodutide vs tirzepatide" }, { "@type": "MedicalIndication", "name": "survodutide FDA approval" }, { "@type": "MedicalIndication", "name": "survodutide clinical trials" } ], "url": "https://pausereset.com/learn/survodutide" }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is survodutide?", "acceptedAnswer": { "@type": "Answer", "text": "Survodutide is a dual GLP-1/glucagon receptor agonist in Phase 3 clinical trials. It combines appetite reduction (GLP-1) with increased energy expenditure and hepatic fat clearance (glucagon). Phase 3 data shows approximately 19% weight loss and dramatic liver fat reduction — making it uniquely positioned for metabolic health beyond just weight." } }, { "@type": "Question", "name": "How does survodutide compare to tirzepatide and retatrutide?", "acceptedAnswer": { "@type": "Answer", "text": "Tirzepatide (GLP-1+GIP) focuses on appetite and insulin. Retatrutide (GLP-1+GIP+glucagon) produces the highest weight loss (28.7%). Survodutide (GLP-1+glucagon) produces strong weight loss (19%) WITH the most dramatic liver fat clearance. Each has a different strength profile — survodutide's unique advantage is the liver/NASH angle." } }, { "@type": "Question", "name": "When will survodutide be FDA approved?", "acceptedAnswer": { "@type": "Answer", "text": "Based on current Phase 3 trial timelines, FDA approval is estimated for 2027-2028. No specific submission date has been announced by Boehringer Ingelheim. Survodutide is not widely available through compounding or research channels in the interim." } } ] } ] --- [![pause + reset](/assets/logo-Cj2twgJt.webp)](/) Symptoms Treatments Atlanta [About](/about) Book [Home](/)[Learn](/learn)Survodutide What It IsWhy It Matters for MenopauseTimeline & AvailabilityFAQ Learn ![Survodutide dual agonist GLP-1 glucagon pathway illustration showing healthy liver and fat droplet clearance — weight loss and liver health medication for menopause](/assets/learn-survodutide-DTt1OHJf.webp "Survodutide — the dual agonist targeting weight loss and liver health") # Survodutide: The Weight Loss Medication That Also Fixes Your Liver Survodutide is a dual GLP-1/glucagon receptor agonist from Boehringer Ingelheim — and what makes it unique in the next-gen GLP-1 landscape is its liver angle. While retatrutide activates three receptors (GLP-1+GIP+glucagon) and tirzepatide activates two (GLP-1+GIP), survodutide activates GLP-1+glucagon. The glucagon component specifically promotes hepatic fat clearance — making survodutide particularly relevant for women dealing with menopause-related fatty liver disease. Phase 3 trials are showing approximately 19% weight loss AND dramatic reductions in liver fat. Here's the full picture. 5 min read ![Dr. Nina Ross](/assets/dr-nina-medspa-v2-DCgjiRes.webp) 🎧 Quick Listen 3:30 ### Survodutide — The Liver Angle Why this dual agonist is different from the rest Read Transcript Want to understand all the GLP-1 options available now? Our Hormones Won't Weight guide covers the metabolic landscape. [Get the Free Guide](/guides/hormones-weight) What It Is ## How Survodutide Differs From the Other Next-Gen GLP-1s The GLP-1 medication landscape is expanding rapidly. Semaglutide (single agonist) was first. Tirzepatide (dual GLP-1/GIP) was second. Now we're seeing the next generation: survodutide (dual GLP-1/glucagon) from Boehringer Ingelheim and retatrutide (triple GLP-1/GIP/glucagon) from Eli Lilly. Survodutide's specific combination — GLP-1 plus glucagon — is designed for two things: weight loss AND liver fat clearance. The GLP-1 component reduces appetite and improves insulin sensitivity (the familiar mechanism from semaglutide). The glucagon component increases energy expenditure, promotes fat oxidation, and — critically — drives hepatic fat clearance. Your liver actively processes and eliminates stored fat. This liver angle is why survodutide has a separate clinical trial program specifically for NASH/MASH (metabolic dysfunction-associated steatohepatitis — commonly called fatty liver disease). Phase 2 data showed that survodutide produced liver fat reduction of 80%+ in many participants, with a significant percentage achieving complete resolution of fatty liver. These numbers are extraordinary. Phase 3 weight loss data shows approximately 19% body weight loss — less than retatrutide's 28.7% but more than semaglutide's 15-17%. The value proposition of survodutide isn't maximum weight loss — it's the combination of meaningful weight loss WITH liver-specific metabolic benefit. Why It Matters for Menopause ## The Fatty Liver Connection Nobody's Talking About During menopause, the prevalence of non-alcoholic fatty liver disease (NAFLD) increases significantly. Estrogen protects against hepatic fat accumulation. When estrogen declines, liver fat storage increases — even in women who drink little or no alcohol. Some estimates suggest 40-60% of postmenopausal women have some degree of hepatic fat accumulation. Fatty liver isn't just a liver problem. It drives systemic inflammation, worsens insulin resistance, impairs cholesterol metabolism, and increases cardiovascular risk. It's one of the most consequential and least discussed metabolic shifts of menopause. A medication that specifically addresses hepatic fat clearance — not just weight loss — is mechanistically targeted at one of the most significant metabolic risks of the hormonal transition. This is what makes survodutide interesting from a menopause medicine perspective, even though the clinical trials haven't specifically studied menopausal women. Timeline & Availability ## When Will Survodutide Be Available? Survodutide is currently in Phase 3 clinical trials for both obesity and NASH/MASH. Boehringer Ingelheim has not announced a specific FDA submission timeline, but based on trial completion projections, availability is estimated for 2027-2028 — a similar timeframe to retatrutide. Unlike retatrutide, survodutide is not widely available through research peptide channels. Its dual agonist structure is less commonly compounded. This means the wait for legitimate access is more dependent on FDA approval than on gray-market availability. In the meantime, women concerned about liver fat and metabolic health can address these issues through: hormonal optimization (estrogen restoration protects against hepatic fat), dietary strategies (reducing refined carbs, alcohol, and increasing omega-3s), targeted supplements (berberine, NAD+, and milk thistle support liver metabolism), and current GLP-1 medications (semaglutide and tirzepatide both improve liver fat to varying degrees, though not as dramatically as survodutide's glucagon-mediated mechanism). ## Frequently Asked Questions ### What is survodutide? ### How does survodutide compare to tirzepatide and retatrutide? ### When will survodutide be FDA approved? ### Related Symptoms ### Other Treatments - [GLP-1 Weight Loss Medications](/treatments/glp-1-weight-loss) ### Related Articles - [Retatrutide: The Triple Agonist](/learn/retatrutide) - [Peptides for Weight Loss](/learn/peptides-weight-loss) - [Berberine Explained](/learn/berberine) - [Orforglipron: The GLP-1 Pill](/learn/orforglipron) Want to understand all the GLP-1 options available now? Our Hormones Won't Weight guide covers the metabolic landscape. [Get the Free Guide](/guides/hormones-weight) Concerned about metabolic health and liver function during menopause? Book your evaluation for comprehensive metabolic labs. [Schedule Your Evaluation](/understand) ![Dr. Nina Ross](/assets/dr-nina-medspa-v2-DCgjiRes.webp) [pause + reset ](/) Personalized hormone optimization and functional medicine for women who refuse to "just deal with it." 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