--- title: "EBOO Therapy — What It Is, Benefits, Cost & Process" description: "What is EBOO therapy? Complete guide to extracorporeal blood oxygenation and ozonation — how it works, benefits, and why it matters in menopause." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": [ "MedicalBusiness", "LocalBusiness" ], "name": "Pause & Reset", "description": "Atlanta's dedicated perimenopause and menopause practice offering bioidentical hormone therapy, comprehensive hormone testing, GLP-1 weight loss management, peptide therapy, IV nutrient therapy, hyperbaric oxygen therapy, and functional medicine in Dunwoody GA.", "url": "https://pausereset.com", "telephone": "+14044458344", "email": "hello@pausereset.com", "image": "https://pausereset.com/assets/logo-Cj2twgJt.webp", "priceRange": "$$$$", "paymentAccepted": "Cash, Credit Card", "currenciesAccepted": "USD", "openingHours": [ "Mo-Fr 10:00-16:30", "Sa 09:00-15:30" ], "address": { "@type": "PostalAddress", "streetAddress": "8735 Dunwoody Place, Suite 110", "addressLocality": "Atlanta", "addressRegion": "GA", "postalCode": 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filtration therapy for inflammation, immune support, and detoxification during perimenopause and menopause." }, { "@type": "MedicalTest", "name": "Comprehensive Hormone Testing", "description": "15+ marker hormone panel including estradiol, progesterone, testosterone, full thyroid, insulin, and nutrient levels." }, { "@type": "MedicalTest", "name": "DUTCH Hormone Testing", "description": "Dried urine testing for hormone metabolism pathways showing how the body processes and clears estrogen." }, { "@type": "MedicalTherapy", "name": "Pelvic Floor Rehabilitation", "description": "Treatment for urinary leaking, urgency, and painful intercourse caused by menopause-related tissue and muscle changes." }, { "@type": "MedicalTherapy", "name": "Medical Weight Loss", "description": "Comprehensive metabolic evaluation and treatment for menopause-related weight gain including hormones, GLP-1, and nutrition." }, { "@type": "MedicalTherapy", "name": "Nutrition and Metabolic Counseling", "description": "Personalized nutrition, supplementation, and metabolic strategy for women in perimenopause and menopause." } ] }, "sameAs": [ "https://www.instagram.com/pausenresetco", "https://atlantatrichology.com", "https://ninaross.co" ], "founder": { "@type": "Person", "name": "Dr. Nina Ross", "jobTitle": "Menopause Specialist", "url": "https://ninaross.co", "sameAs": [ "https://ninaross.co", "https://atlantatrichology.com" ] } }, { "@context": "https://schema.org", "@type": "MedicalTherapy", "name": "EBOO therapy", "description": "What is EBOO therapy? Complete guide to extracorporeal blood oxygenation and ozonation — how it works, benefits, and why it matters in menopause.", "indication": [ { "@type": "MedicalIndication", "name": "EBOO" }, { "@type": "MedicalIndication", "name": "EBOO treatment" }, { "@type": "MedicalIndication", "name": "EBOO ozone therapy" }, { "@type": "MedicalIndication", "name": "EBOO blood treatment" } ], "url": "https://pausereset.com/treatments/eboo-ozone-therapy" }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is EBOO therapy?", "acceptedAnswer": { "@type": "Answer", "text": "EBOO (Extracorporeal Blood Oxygenation and Ozonation) is an advanced ozone therapy that draws your blood through a medical-grade dialysis filter — removing inflammatory proteins, heavy metals, and metabolic waste — while simultaneously saturating it with medical ozone. The filtered, ozone-enriched blood is returned to your body. It's the most comprehensive form of ozone therapy available, combining physical filtration with ozone-mediated biological activation." } }, { "@type": "Question", "name": "What are the benefits of EBOO therapy?", "acceptedAnswer": { "@type": "Answer", "text": "EBOO reduces systemic inflammation (measurable on lab work), supports detoxification (physical removal of toxins through filtration), modulates immune function (balancing overactive and underactive immune responses), enhances oxygen delivery (improved red blood cell function), upregulates antioxidant defenses (SOD, catalase, glutathione peroxidase), and improves energy and mental clarity. During perimenopause and menopause, every one of these functions is especially valuable because estrogen decline compromises them." } }, { "@type": "Question", "name": "What is the difference between EBOO and regular ozone therapy?", "acceptedAnswer": { "@type": "Answer", "text": "Traditional ozone therapy (MAH) treats a small volume of blood (100-250ml) mixed with ozone in a bag. EBOO processes your entire blood volume through a dialysis-grade filter while simultaneously infusing ozone. The filtration component — physically removing inflammatory proteins and toxins — is unique to EBOO and is what makes it significantly more comprehensive and powerful than MAH." } }, { "@type": "Question", "name": "How much does EBOO therapy cost?", "acceptedAnswer": { "@type": "Answer", "text": "Individual EBOO sessions typically range from $400-$1,200 depending on the provider, equipment quality, and whether the session is standalone or part of a comprehensive plan. At Pause & Reset, pricing is transparent and discussed before treatment begins. Integrated EBOO — coordinated with hormone therapy and other modalities — typically produces better results per session than standalone treatment." } }, { "@type": "Question", "name": "What are EBOO therapy side effects?", "acceptedAnswer": { "@type": "Answer", "text": "The most common experience is mild fatigue or a low-grade headache the evening of the session, especially the first treatment — representing the body processing mobilized toxins. This typically resolves within 12-24 hours. Some women experience a brief Herxheimer-like reaction (temporary symptom intensification) in early sessions. Serious adverse events are rare with properly administered protocols." } }, { "@type": "Question", "name": "How many EBOO sessions do I need?", "acceptedAnswer": { "@type": "Answer", "text": "Most protocols involve 4-8 weekly sessions followed by monthly or quarterly maintenance. Protocol length depends on your inflammatory markers and clinical response. Some women notice shifts after 1-2 sessions. Sustained, measurable benefits (reduced hs-CRP, improved energy, enhanced clarity) build over the full series." } }, { "@type": "Question", "name": "Is EBOO therapy FDA approved?", "acceptedAnswer": { "@type": "Answer", "text": "EBOO uses FDA-cleared medical devices (dialysis-grade filters and ozone generators) in an off-label application. Ozone therapy is widely practiced in integrative and functional medicine and is regulated at the state level. At Pause & Reset, EBOO is performed with medical-grade equipment under clinical supervision following established protocols." } }, { "@type": "Question", "name": "Can I combine EBOO with other treatments?", "acceptedAnswer": { "@type": "Answer", "text": "Yes — and combinations are often recommended. EBOO pairs especially well with HBOT (double oxygenation from two directions), IV glutathione (supports clearance of mobilized toxins), IV NAD+ (cellular energy amplification), and bioidentical hormone therapy (restored signaling in a cleaner environment). We coordinate scheduling so you can accomplish multiple therapies in a single visit." } } ] } ] --- [![pause + reset](/assets/logo-Cj2twgJt.webp)](/) Symptoms Treatments Atlanta [About](/about) Book [Home](/)Treatments EBOO Ozone Therapy What It IsHow It WorksEBOO vs Other Ozone TherapiesWhy During MenopauseBenefitsWhat to ExpectSide EffectsCostOur ApproachFAQ Treatment Guide ![EBOO ozone therapy equipment with medical-grade dialysis filter and blood oxygenation unit — advanced blood filtration and ozonation treatment](/assets/treatment-eboo-D_Nn2Mg2.webp "EBOO Ozone Therapy — your blood, filtered and oxygenated") # EBOO Therapy — What It Is, How It Works, and Why It's One of the Most Powerful Recovery Tools Available During the Hormonal Transition EBOO — Extracorporeal Blood Oxygenation and Ozonation — is an advanced ozone therapy that filters your blood through a medical-grade dialysis membrane while saturating it with ozone. The result: cleaner blood, enhanced oxygen delivery, reduced systemic inflammation, immune modulation, and upregulated antioxidant defenses. Every one of those functions becomes more valuable during perimenopause and menopause, when estrogen decline compromises the body's inflammation control, detoxification pathways, and immune regulation. 10 min read ## Symptom Snapshot What It Is Blood filtered through dialysis membrane + saturated with ozone, returned cleaner Session 45-60 min, full blood volume Key Benefits Inflammation, detox, immune balance, oxygenation, antioxidant defense Why During Menopause Estrogen decline weakens every system EBOO supports vs MAH Filters + ozonates entire blood volume. MAH treats a small sample. Wondering if EBOO belongs in your protocol? Our free guide, Advanced Therapies for Menopause Relief, walks you through the options. [Get the Advanced Therapies Guide](/guides/advanced-therapies-menopause.pdf) What It Is ## What Is EBOO Therapy? EBOO stands for Extracorporeal Blood Oxygenation and Ozonation. 'Extracorporeal' means 'outside the body.' During an EBOO session, blood is drawn from one arm, passed through a medical-grade dialysis filter that physically removes inflammatory proteins, metabolic waste products, and heavy metals. Simultaneously, medical-grade ozone (O3) is infused into the blood — dissolving into plasma and binding to red blood cells. The filtered, ozone-enriched blood is then returned to your body through the other arm. The process treats your entire blood volume over the course of a 45-60 minute session. What makes EBOO distinct from other ozone therapies is the FILTRATION component — the dialysis membrane physically removes substances from the blood that ozone alone cannot address. You're receiving both purification and oxygenation in a single treatment. EBOO is the most advanced form of ozone therapy currently available. It evolved from earlier ozone protocols — Major Autohemotherapy (MAH) and Minor Autohemotherapy — which treated smaller blood volumes without the filtration component. The combination of dialysis-grade filtration with ozone saturation makes EBOO significantly more powerful than its predecessors. > "I could literally see the difference — the blood going in was dark and what came back was bright red. Afterward I felt 10 pounds lighter. The brain fog cleared in a way I hadn't experienced from any other single treatment." > > — Age 48, Sandy Springs How It Works ## The Mechanism: Filtration, Ozonation, and the Cascade They Trigger THE FILTRATION PATHWAY: The medical-grade dialysis membrane separates your blood from unwanted substances based on molecular size. Inflammatory cytokines, oxidized lipids, immune complexes, heavy metal particles, and metabolic waste products are trapped by the filter — physically removed from circulation. This immediate reduction in circulating inflammatory and toxic load is one reason women often feel tangibly lighter and clearer after a session. THE OZONATION PATHWAY: Medical-grade ozone (O3) is a highly reactive form of oxygen. When introduced into blood, ozone reacts with lipids in the plasma to form ozonides and lipid peroxidation products — which sounds concerning but is actually the therapeutic mechanism. These controlled oxidative stress signals trigger your body's antioxidant defense system to upregulate: superoxide dismutase (SOD), catalase, and glutathione peroxidase all increase activity. This is the hormesis principle — a small, controlled stress triggers a disproportionately large protective response. THE IMMUNE MODULATION PATHWAY: Ozone exposure modulates immune cell behavior. It stimulates monocytes and lymphocytes to produce cytokines that improve immune surveillance while simultaneously dampening the overproduction of pro-inflammatory cytokines (TNF-alpha, IL-1, IL-6). For women in perimenopause — when immune dysregulation can trigger autoimmune flares, increased susceptibility to infection, and chronic low-grade inflammation — this immune-balancing effect is especially valuable. THE OXYGEN DELIVERY PATHWAY: Ozone increases the flexibility and oxygen-releasing capacity of red blood cells by enhancing the production of 2,3-diphosphoglycerate (2,3-DPG), which facilitates oxygen release from hemoglobin to tissues. Your red blood cells become more efficient oxygen delivery vehicles — improving tissue oxygenation throughout the body, including the brain, muscles, and organs. EBOO vs Other Ozone Therapies ## How EBOO Compares to MAH and Other Ozone Treatments MAJOR AUTOHEMOTHERAPY (MAH): The most common ozone therapy. A small volume of blood (100-250ml) is drawn, mixed with ozone in a bag or syringe, and reinfused. MAH is effective for immune modulation and mild oxygenation but treats only a fraction of your blood volume and includes zero filtration. Think of it as a targeted dose versus EBOO's comprehensive treatment. MINOR AUTOHEMOTHERAPY: An even smaller volume of blood (2-5ml) is mixed with ozone and injected intramuscularly. Used primarily for immune stimulation. Significantly less comprehensive than either MAH or EBOO. OZONE SAUNA / INSUFFLATION: Ozone delivered topically (through skin) or into body cavities (rectal, vaginal, ear). These methods deliver ozone locally and systemically through absorption. They have their place in clinical practice but lack the blood filtration and the volume of ozone-blood contact that EBOO delivers. EBOO: Processes your entire blood volume through a dialysis-grade filter while simultaneously saturating it with ozone. The only ozone therapy that combines FILTRATION (physical removal of inflammatory proteins and toxins) with OZONATION (ozone-mediated biological cascade). The most comprehensive, most powerful, and most advanced ozone modality available. The analogy: if MAH is changing the oil in your car, EBOO is changing the oil AND replacing the filter AND running a fuel system cleaner — all at once. Why During Menopause ## Why EBOO Becomes Especially Valuable During Perimenopause and Menopause Estrogen is a master inflammation regulator. It modulates NF-kB signaling (a central inflammatory pathway), supports antioxidant enzyme activity, maintains liver detoxification capacity, and regulates immune cell behavior. When estrogen declines during the menopausal transition, each of these functions weakens — producing the chronic low-grade inflammation that drives cardiovascular risk, joint pain, brain fog, fatigue, and metabolic dysfunction. EBOO directly addresses the inflammation and detoxification gaps that estrogen decline creates. The filtration removes circulating inflammatory proteins that are elevated because estrogen has stepped back from regulating them. The ozonation upregulates the antioxidant defense systems that estrogen used to support. The immune modulation rebalances the immune dysregulation that surfaces during the transition. For women with elevated hs-CRP, persistent joint inflammation, brain fog unresponsive to hormonal optimization alone, chronic fatigue with a suspected toxic or inflammatory component, or immune challenges (frequent illness, autoimmune flares), EBOO provides a direct intervention that supports the terrain while hormone therapy restores the signaling. The combination of EBOO with bioidentical hormone therapy is the advanced play: hormones restore what was lost, EBOO cleans and oxygenates the environment those hormones operate in. The two therapies address the same underlying challenge — menopause-driven system decline — through entirely different and complementary mechanisms. Benefits ## The Benefits of EBOO Therapy INFLAMMATION REDUCTION: Direct removal of inflammatory cytokines through filtration PLUS downregulation of pro-inflammatory mediators through ozone-induced immune modulation. Measurable on hs-CRP and cytokine panels. Women with elevated inflammatory markers often see significant reductions over a series of sessions. DETOXIFICATION SUPPORT: Physical removal of heavy metals, metabolic waste, and oxidized lipids through the dialysis membrane. Enhanced liver support through ozone-mediated upregulation of Phase I and Phase II detoxification enzymes. For women whose detoxification capacity has slowed with estrogen decline, EBOO provides a direct assist. IMMUNE REGULATION: Ozone modulates immune cell behavior — stimulating surveillance functions while dampening overactive inflammatory responses. This balancing effect is especially relevant during perimenopause when immune dysregulation can trigger autoimmune activation (Hashimoto's thyroiditis frequently surfaces during the transition), increased susceptibility to infection, and chronic inflammatory states. ENHANCED OXYGEN DELIVERY: Improved red blood cell flexibility and oxygen-releasing capacity means better tissue oxygenation throughout the body. The brain, muscles, joints, and organs all benefit from enhanced oxygen delivery — translating to improved cognitive clarity, physical energy, exercise recovery, and wound healing. ANTIOXIDANT UPREGULATION: The controlled oxidative stress from ozone triggers a robust antioxidant defense response — increasing SOD, catalase, and glutathione peroxidase activity. This hormetic response strengthens your body's own protective systems, creating lasting resilience beyond the immediate session effects. ENERGY AND RECOVERY: The combination of improved oxygenation, reduced inflammatory load, and enhanced mitochondrial support translates to tangible energy improvements. Many women describe a specific quality of vitality after EBOO — cleaner, steadier energy that feels fundamentally different from stimulant-driven alertness. What to Expect ## What an EBOO Session Looks and Feels Like You'll recline in a comfortable treatment chair while two IV lines are placed — one in each arm. One line draws blood out, the other returns it. The EBOO unit sits beside you with the filtration chamber and ozone generator visible. The process takes 45-60 minutes, during which you can watch the filtration in real time — blood enters the filter one color and exits visibly brighter as inflammatory proteins and waste are removed. The visual transformation is one of the most striking aspects of EBOO. Patients frequently remark on the color difference between the blood entering and leaving the filter. It's a tangible, visible demonstration of what the therapy is doing. During the session, most women read, listen to music, or relax. The process is calm and fully supervised. Afterward, many describe immediate mental clarity and a feeling of lightness. Some experience mild fatigue or a low-grade headache the evening of their first session — a normal response as the body processes mobilized toxins. Energy typically rebounds strongly the following day, with cumulative improvements over subsequent sessions. Most clinical protocols involve a series of weekly sessions (typically 4-8), followed by maintenance at monthly or quarterly intervals. Protocol length and frequency are guided by your inflammatory markers and clinical response. ### Symptom Tracker — EBOO Ozone Therapy Track these for 2–4 weeks before your appointment Primary goal — Inflammation? Detox? Immune support? Energy? Brain fog? Knowing the target shapes your protocol. Current treatment — Already on hormone therapy? HBOT? IV nutrients? EBOO layers onto and amplifies these. Inflammatory markers — hs-CRP, ESR, cytokine panel results? We track these before and during EBOO. Toxic exposure history — Environmental exposures, occupational history, dental amalgams? These inform the filtration priority. Immune status — Autoimmune conditions? Frequent illness? Immune challenges during the transition? 💾 Save this tracker — bring it to your first appointment Side Effects ## EBOO Therapy Side Effects and Safety EBOO has a favorable safety profile when performed by trained providers using medical-grade equipment. The most commonly reported experience is mild fatigue or a low-grade headache the evening of the session — especially after the first treatment. This represents the body processing mobilized toxins and typically resolves within 12-24 hours. Adequate hydration before and after sessions helps minimize this response. Some women experience a brief Herxheimer-like reaction (a temporary intensification of symptoms as toxins are mobilized faster than they can be cleared) — particularly in early sessions. This is generally mild and self-limiting, and it typically diminishes with subsequent sessions as the toxic load decreases. IV site discomfort (bruising, minor soreness at the needle insertion points) is possible, as with any IV procedure. Proper IV technique and post-procedure care minimize this. Serious adverse events with EBOO are rare when protocols are followed appropriately. Pre-session screening at Pause & Reset includes blood pressure assessment, review of coagulation status and medications (blood thinners require specific protocol considerations), and evaluation of overall clinical suitability. Cost ## How Much Does EBOO Therapy Cost? EBOO therapy pricing varies by provider and region. Individual EBOO sessions in the United States typically range from $400 to $1,200 per session, with pricing influenced by equipment quality, clinical supervision level, and whether the session is standalone or part of a comprehensive protocol. At Pause & Reset, EBOO is offered within your comprehensive care plan. Session pricing depends on protocol length and whether EBOO is combined with complementary therapies (IV glutathione, HBOT, hormone management). We're transparent about all costs before treatment begins — complete clarity from the outset. Many women find that integrated EBOO — where the therapy coordinates with hormonal optimization, nutritional support, and metabolic management — produces significantly better outcomes per session than standalone EBOO at a separate facility. When the system being cleaned is also the system being restored, each therapy multiplies the other's effectiveness. Our Approach ## EBOO at Pause & Reset — Prescribed by Your Inflammation, Measured by Your Results At Pause & Reset, EBOO is recommended when your lab data indicates that systemic inflammation, immune dysregulation, or toxic burden are contributing to your symptom picture. We track inflammatory markers (hs-CRP, cytokine panels), immune function indicators, and metabolic markers before, during, and after your EBOO protocol — because every advanced therapy earns its place through measurable improvement. Your EBOO protocol integrates with your bioidentical hormone therapy, your nutritional strategy, your IV nutrient sessions, and potentially your HBOT protocol — creating a layered approach where each therapy amplifies the others. Hormones restore the signaling. EBOO cleans and oxygenates the terrain. IV nutrients provide the raw materials. HBOT drives oxygen into tissues. The whole system compounds. Our EBOO equipment is medical-grade, operated by trained clinical staff at the Pause & Reset wellness center in Sandy Springs, Georgia. Serving women across the greater Atlanta metro who are ready for the most advanced level of integrative menopause care available. ## Frequently Asked Questions ### What is EBOO therapy? ### What are the benefits of EBOO therapy? ### What is the difference between EBOO and regular ozone therapy? ### How much does EBOO therapy cost? ### What are EBOO therapy side effects? ### How many EBOO sessions do I need? ### Is EBOO therapy FDA approved? ### Can I combine EBOO with other treatments? ### Related Symptoms - [Perimenopause Fatigue](/symptoms/perimenopause-fatigue) - [Menopause Brain Fog](/symptoms/menopause-brain-fog) - [Menopause and Cortisol](/conditions/menopause-cortisol) - [Menopause Joint Pain](/symptoms/perimenopause-joint-pain) ### Other Treatments - [EBOO Ozone Therapy in Atlanta](/atlanta/eboo-ozone-therapy) - [Hyperbaric Oxygen Therapy](/treatments/hyperbaric-oxygen-therapy) - [IV Nutrient Therapy](/treatments/iv-therapy) - [Bioidentical Hormone Therapy](/treatments/bioidentical-hormone-therapy) ### Atlanta Care - [EBOO Ozone Therapy in Atlanta](/atlanta/eboo-ozone-therapy) - [Menopause Specialist in Atlanta](/atlanta/menopause-specialist) Wondering if EBOO belongs in your protocol? Our free guide, Advanced Therapies for Menopause Relief, walks you through the options. [Get the Advanced Therapies Guide](/guides/advanced-therapies-menopause.pdf) Ready to explore the most advanced ozone therapy available? Book your comprehensive evaluation. [Schedule Your Evaluation](/understand) ![Dr. Nina Ross](/assets/dr-nina-medspa-v2-DCgjiRes.webp) [pause + reset ](/) Personalized hormone optimization and functional medicine for women who refuse to "just deal with it." 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